Oct-4 Expression in Adult Human Differentiated Cells Challenges Its Role as a Pure Stem Cell Marker
نویسندگان
چکیده
منابع مشابه
Differentiated human stem cells resemble fetal, not adult, β cells.
Human pluripotent stem cells (hPSCs) have the potential to generate any human cell type, and one widely recognized goal is to make pancreatic β cells. To this end, comparisons between differentiated cell types produced in vitro and their in vivo counterparts are essential to validate hPSC-derived cells. Genome-wide transcriptional analysis of sorted insulin-expressing (INS(+)) cells derived fro...
متن کاملOct-4-expressing cells in human amniotic fluid: a new source for stem cell research?
BACKGROUND It is the hope of investigators and patients alike that in future the isolation of pluripotent human stem cells will allow the establishment of therapeutic concepts for a wide variety of diseases. A major aim in this respect is the identification of new sources for pluripotent stem cells. Oct-4 is a marker for pluripotent human stem cells so far known to be expressed in embryonal car...
متن کاملOct-4 controls cell-cycle progression of embryonic stem cells
Mouse and human ES (embryonic stem) cells display unusual proliferative properties and can produce pluripotent stem cells indefinitely. Both processes might be important for maintaining the 'stemness' of ES cells; however, little is known about how the cell-cycle fate is regulated in ES cells. Oct-4, a master switch of pluripotency, plays an important role in maintaining the pluripotent state o...
متن کاملoct-4: more than a pluripotent marker?
received: 23/sep/2008, accepted: 23/nov/2008oct-4/ pou5f1/ oct-3, a pou domain family protein acts as a crucial transcription factor dur- ing embryonic development. it helps in maintenance of self renewal as well as pluripotential state of embryonic stem (es) cells. its expression starts right from 2 cell stage especially prior to 8 cell stage till the blastocyst stage where it is strongly exp...
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Traumatic brain injury (TBI) leading to 5 million deaths annually is 1 of the 5 major causes of morbidity and mortality worldwide. In Iran, accidents are the main cause of death in youth as well as a dominant factor in reducing quality of life. In developing countries TBI incidence as one of the worst consequences of these accidents is growing due to wide use of motor-vehicles. Therapeutic stra...
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ژورنال
عنوان ژورنال: Stem Cells
سال: 2007
ISSN: 1066-5099,1549-4918
DOI: 10.1634/stemcells.2006-0611